What is a atypical Spitz tumor?
Atypical Spitz tumors (AST) are rare spitzoid melanocytic proliferations with an uncertain malignant potential. ASTs have overlapping features of both Spitz nevi and spitzoid melanoma, and consequently generate controversy with diagnosis and management.
Is a Spitz tumor cancer?
A Spitz nevus is a rare type of skin mole that usually affects young people and children. Although it can look like a serious form of skin cancer called melanoma, a Spitz nevus lesion isn’t considered cancerous.
Is a Spitz nevus bad?
There is debate as to whether the PSCNOR is an entity in its own right or whether it is a variation of a Spitz naevus. Although both lesions are benign, they can have similar clinical and histopathological features to melanoma, making their assessment difficult and best left in the hands of a specialist.
Is Spitzoid melanoma aggressive?
Although there is a paucity of data, several smaller studies have suggested spitzoid melanomas are less aggressive and have a lower mortality rate when compared with conventional malignant melanoma, he said.
How fast does Spitzoid melanoma grow?
Most Spitz tumors occur in patients younger than 20 years. In those who are in their 20s and 30s who have Spitz nevi, there is a greater likelihood of malignancy in the lesion. Clinically, Spitzoid melanomas are usually changing amelanotic nodular lesions, and can grow fairly rapidly over several months.
Is Spitz nevus genetic?
Genetic aberrations can be found in the entire biological spectrum of spitzoid neoplasms (i.e. Spitz nevi, atypical Spitz tumors and spitzoid melanoma) and are, therefore, probably not useful for distinguishing benign from malignant tumors; however, genetic aberrations represent important targets for therapeutic …
How often is Spitz nevus misdiagnosed?
Even if the biopsies are sometimes performed, owing to the overlap histopathologic features between melanoma and benign nevus, misdiagnosis is often. One study showed that up to 40% of children originally diagnosed with Spitz nevi were later found to have melanomas .
What is atypical Spitz nevus?
Atypical Spitz nevi are described as conventional Spitz nevi with 1 or more atypical features with indeterminate biological potential. Features of atypical Spitz include larger size (>6 mm), irregular borders, irregular topography, or ulceration.
What is a typical compound Spitz nevus?
Spitz nevus, compound type. This tumor from the arm of a 4-year-old contains a dense epithelioid melanocytic proliferation with features that overlap with those of melanoma: pagetoid growth and transepidermal elimination of melanocytic nests resembling so-called consumption of the epidermis.
What is a Spitzoid lesion?
Spitzoid melanoma presents as a changing and enlarging papule or nodule. It can be amelanotic (nonpigmented, red) or pigmented (brown, black or blue). Advanced Spitzoid melanoma may be crusted and ulcerated. It is most often located on the head or extremities.
Is Merkel cell carcinoma fatal?
Merkel cell carcinoma, or MCC, is a rare skin cancer that can be fatal, killing about 700 people per year. It occurs more commonly in people frequently exposed to ultraviolet light. Most cases of MCC show up first with a small red or purple bump on the skin.
What is a Spitz nevus?
Spitz nevus (Epithelioid and Spindle-Cell Nevus) is an uncommon, benign, melanocytic nevus that is usually acquired and has histologic features that overlap with those of melanoma.
What is dysplastic mole?
A specific type of nevus (mole) that looks different from a common mole. Dysplastic nevi are mostly flat and often larger than common moles and have borders that are irregular. A dysplastic nevus can contain different colors, which can range from pink to dark brown.
What is a blue Naevus?
The blue nevus is a solitary blue-colored mole that can present at birth or develop later on in life. It can remain unchanged throughout the duration of a person’s life.