What does refractory mean in cancer?

How does cancer become refractory?

The meaning of refractory cancer is cancer that fails to respond to medical treatment. This may present as resistance to treatment from the start, or the acquisition of resistance by the cancer cells during the course of therapy. Refractory cancer is also called resistant cancer.

What does refractory mean in medical terms?

Listen to pronunciation. (reh-FRAK-tor-ee) In medicine, describes a disease or condition that does not respond to treatment.

What is a refractory solid tumor?

The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. Refractory cancer refers to cancer that may be resistant at the beginning of treatment, or becomes resistant during treatment.

What does it mean to fail chemotherapy?

Chemotherapy resistance occurs when cancers that have been responding to a therapy suddenly begin to grow. In other words, the cancer cells are resisting the effects of the chemotherapy. You may hear statements like the “cancer chemotherapy failed.” When this occurs, the drugs will need to be changed.

What are refractory symptoms?

A refractory symptom is one that cannot be adequately controlled despite aggressive efforts to identify a tolerable therapy that does not compromise consciousness (Cherny 1994). A refractory symptom may be subjective and, at times, nonspecific.

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What is treatment refractory disease?

Patients with “treatment resistant” or “treatment refractory” disorders are those who do not respond to the usual first- and even second- and third-line treatments. Many people whose lives have been adversely affected by psychiatric illness struggle with a range of difficulties that may include.

What does relapsed/refractory mean?

Relapsed CLL is the term for disease that responded to therapy but, after 6 or more months, stopped responding. Refractory disease is the term for CLL that does not result in a remission (but may be stable) or disease that gets worse within 6 months of the last treatment.

What does highly refractory mean?

1 : resisting control or authority : stubborn a refractory child. 2 : capable of enduring very high temperatures refractory clays. refractory. adjective.

What is primary refractory disease?

Primary refractory Hodgkin’s disease may generally be defined as progression of disease during induction treatment or a partial or transient response (< 60 days) to induction therapy. Salvage chemotherapy is inadequate in this patient population; fewer than 10% of patients survive for 10 years or longer.

What is the synonym of refractory?

Some common synonyms of refractory are headstrong, intractable, recalcitrant, ungovernable, unruly, and willful. While all these words mean “not submissive to government or control,” refractory stresses resistance to attempts to manage or to mold.