What does marginal zone lymphoma mean?

Can marginal zone lymphoma be cured?

Most patients with nodal marginal zone lymphoma present with advanced stage disease and are not likely to achieve cure, even with aggressive chemotherapy regimens. Moreover, there is little evidence that choice of initial therapy has any impact on survival.

Is marginal zone lymphoma always a cancer?

Marginal zone lymphomas are types of slow-growing (low-grade) non-Hodgkin lymphomas that develop from B cells. They are called marginal zone lymphomas because they develop in a particular region found at the edge of normal lymphoid tissues (collections of lymphocytes) called the marginal zone.

What causes marginal zone lymphoma?

The causes of nodal marginal zone lymphoma (NMZL) are mostly unknown. It is sometimes linked to long-term infection with the hepatitis C virus (HCV). But it is important to remember that most people with HCV will not develop lymphoma. NMZL can affect people of all ages but is most common in people over the age of 50.

How long can you live with marginal zone lymphoma?

Extranodal marginal zone B-cell lymphomas have a slightly better outcome than the other types. Almost 90 out of 100 people with this type of marginal zone lymphoma (90%) survive for 5 years or more after they are diagnosed.

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What are the symptoms of marginal zone lymphoma?

Symptoms of marginal zone lymphoma (MZL)

  • Enlarged lymph nodes.
  • Fatigue.
  • Unexplained loss of weight.
  • Skin rash or itching of the skin.
  • Pains in the chest, abdomen (stomach) or bones for no obvious reason.
  • Fever for no known reason eg. Infection.
  • Drenching night sweats.

How common is marginal zone lymphoma?

MZL accounts for 6% (literature ranges from 2 to 12%) of all B-cell lymphomas. Of the extranodal sites, the most common is stomach/gastric (GALT lymphoma) followed by ocular/adnexal, lung, skin, and salivary gland, the median age of a MZL diagnosis is 67 years and is slightly more common in men.

Can marginal zone lymphoma spread?

This is called gastric MALT lymphoma. Less commonly, it can develop in the small bowel, salivary gland, thyroid gland, tear glands or lungs. These lymphomas tend not to spread beyond the place where they started. This type of marginal zone lymphoma starts within the lymph nodes.

Is nodal marginal zone lymphoma fatal?

NMZL is characterized by an indolent course, but its prognosis is generally considered less favorable than that of SMZL and MALT lymphoma, with reported 5-year overall survival rates ranging between 55% and 89%.

What is Stage 4 marginal zone lymphoma?

The Ann Arbor staging system is commonly used for Hodgkin’s lymphoma patients. It has also been used for the treatment of NHL, including MZL. The Ann Arbor staging system Stage IV indicates diffuse or disseminated involvement of one or more extra-lymphatic organs, including any involvement of the liver or bone marrow.

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What is the life expectancy for someone with lymphoma?

The overall 5-year relative survival rate for people with NHL is 72%. But it’s important to keep in mind that survival rates can vary widely for different types and stages of lymphoma.

5-year relative survival rates for NHL.

SEER Stage 5-Year Relative Survival Rate
All SEER stages combined 89%

How do you treat extranodal marginal zone lymphoma?

Low-dose radiation therapy (4 Gy in 2 fractions) is used increasingly in the treatment of localized extranodal indolent lymphomas: although the progression-free survival (PFS) rate with 4 Gy is ∼75% at 5 years, local PFS remains inferior to that obtained with 24 Gy.