What are the main problems that can occur as a result of tumor lysis syndrome?

What are complications of tumor lysis syndrome?

Potential complications of tumor lysis syndrome include uremia and oliguric renal failure due to tubule precipitation of uric acid, calcium phosphate, or hypoxanthine. Severe electrolyte disturbances, such as hyperkalemia and hypocalcemia, predispose patients to cardiac arrhythmia and seizures.

What symptoms might the patient have with tumor lysis syndrome?

Symptoms

  • nausea.
  • vomiting.
  • diarrhea.
  • muscle cramps or twitches.
  • weakness.
  • numbness or tingling.
  • fatigue.
  • decreased urination.

Which condition is associated with tumor lysis syndrome?

The metabolic derangement associated with tumor lysis syndrome are hyperkalemia, hypocalcemia, hyperphosphatemia, and hyperuricemia. Blood urea nitrogen (BUN), creatinine, and lactate dehydrogenase are also elevated in tumor lysis syndrome.

What are the most common cancers that pose a risk of TLS upon treatment?

Patients with a large “tumor burden” of cancer cells and/or tumors that typically have rapidly dividing cells, such as acute leukemia or high-grade lymphoma, as well as tumors that are highly responsive to therapy, are at greatest risk of developing TLS.

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What is the treatment of Tumour lysis syndrome?

In general, treatment of TLS consists of intensive hydration, stimulation of diuresis, and, more specifically, in the use of allopurinol and rasburicase.

Is tumor lysis syndrome a good thing?

TLS occurs when there is a rapid breakdown of nucleic acids and lysis of tumor cells during or in the days following chemotherapy initiation, resulting in characteristic electrolyte abnormalities. All of these abnormalities can have lethal consequences.

Can you survive tumor lysis syndrome?

Prognosis in tumor lysis syndrome depends on the underlying malignancy characteristics. In patients with a hematologic malignancy, the mortality rate for tumor lysis syndrome is approximately 15%. The reported mortality of tumor lysis syndrome in patients with solid malignancies is reported at 36%.

Can you have tumor lysis syndrome without chemo?

Tumor lysis syndrome (TLS) presenting in absence of chemotherapy is a rare occurrence. One of the true oncological emergencies, it can lead to significant morbidity and mortality. TLS is a phenomena usually associated with tumor cell death after treatment.

Does Tumour lysis syndrome cause pain?

High levels of potassium can lead to neurological changes and heart problems. Uric acid. Excess uric acid (hyperuricemia) can cause kidney stones and kidney damage. You can also develop uric acid deposits in your joints, which causes a painful condition similar to gout.

What is meant by tumor lysis syndrome?

Listen to pronunciation. (TOO-mer LY-sis SIN-drome) A condition that can occur after treatment of a fast-growing cancer, especially certain leukemias and lymphomas (cancers of the blood). As tumor cells die, they break apart and release their contents into the blood.

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Which drugs cause TLS?

Agents reported to cause tumor lysis syndrome include the following:

  • Paclitaxel.
  • Fludarabine.
  • Etoposide.
  • Thalidomide.
  • Bortezomib.
  • Zoledronic acid.
  • Hydroxyurea.
  • Carfilzomib.

Is tumor lysis syndrome an emergency?

Tumor lysis syndrome (TLS) is the most common oncologic emergency. It is caused by rapid tumor cell destruction and the resulting nucleic acid degradation during or days after initiation of cytotoxic therapy.