How does vinblastine kill cancer cells?
Antimicrotubule agents (such as vinblastine), inhibit the microtubule structures within the cell. Microtubules are part of the cell’s apparatus for dividing and replicating itself. Inhibition of these structures ultimately results in cell death.
What is the mechanism of action of vinblastine?
Mechanism of Action
Vinblastine is the salt of an alkaloid extracted from a flowering herb commonly known as periwinkle. Vinblastine is cell cycle phase specific; it binds to microtubular proteins in the mitotic spindle, thereby preventing cell division during metaphase.
How does vinblastine stop mitosis?
Both vincristine and vinblastine bind to the microtubular proteins of the mitotic spindle and prevent cell division during the anaphase of mitosis. They arrest mitosis and cause cell death. The drugs are therefore M-phase cell-cycle specific and their effects are therefore limited to dividing cells.
Is vinblastine used for cancer?
Vinblastine is used to treat cancer. It works by slowing or stopping the growth of cancer cells.
Does vinblastine cause hair loss?
This medicine often causes a temporary loss of hair. After treatment with vinblastine has ended, or sometimes even during treatment, normal hair growth should return.
Does vinblastine cause neuropathy?
Among the Vinca alkaloids, peripheral neuropathy is the principal toxicity of Vincristine and neutropenia of Vinblastine, Vinorelbine, and Vindesine. Vinblastine neuropathy is rare and mild; whereas, Vinorelbine and Vindesine can be associated with moderate neuropathy.
What is the use of vinblastine?
Vinblastine is used in combination with other chemotherapy drugs to treat Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (types of cancer that begin in a type of white blood cell that normally fights infection), and cancer of the testicles.
How do you give vinblastine?
Vinblastine should not be given intramuscularly, subcutaneously or intrathecally. The solution may be injected either directly into the vein or into the injection site of a running intravenous infusion. Injection of vinblastine sulfate may be completed in about one minute. FOR INTRAVENOUS USE ONLY.
What can stop mitosis?
A mitotic inhibitor is a drug that inhibits mitosis, or cell division. These drugs disrupt microtubules, which are structures that pull the chromosomes apart when a cell divides.
What stage of mitosis does colchicine affect?
T h e arrest of mitosis at metaphase
The most striking effect of cold and of colchicine is the arrest of mitosis when the chromosomes have reached metaphase spiralization. This arrest leads to an accumulation of cells at this stage.
How was vinblastine discovered?
Noble was recognized for “his discovery of “vinblastine”‘ (VLB) a drug derived irom the Madagascar periwinkle plant (Vinca mm, now called Catharanthis mm); Beer, “for isolating’ it in 1958. The Hall of Fame tells us that the first clinical trials were conducted at Princess Margaret Hospital in 1959.
What type of chemo is vinblastine?
Drug type: Vinblastine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as a “plant alkaloid.” (For more detail, see “How vinblastine works” section below).
What does dacarbazine do for cancer?
A drug used to treat Hodgkin lymphoma that did not get better with other anticancer drugs and melanoma that has spread to other parts of the body. It is also being studied in the treatment of other types of cancer. Dacarbazine damages the cell’s DNA and may kill cancer cells.